KiSS‐1/GPR54 sensitizes TNFα‐induced apoptotic cell death of invasive tumor cells
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چکیده
منابع مشابه
MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced apoptotic cell death.
Novel therapeutic approaches are urgently needed for high-stage neuroblastoma, a major therapeutic challenge in pediatric oncology. The majority of neuroblastoma tumors are p53 wild type with intact downstream p53 signaling pathways. We hypothesize that stabilization of p53 would sensitize this aggressive tumor to genotoxic chemotherapy via inhibition of MDM2, the primary negative upstream regu...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.820.1